HEM-PRO
Long-term prosthesis survival of total hip and total knee arthroplasty in people with inherited bleeding disorders
Description
In this single center retrospective cohort study, regular care data of total knee arthroplasty and total hip arthroplasty was extracted from medical records of people with bleeding disorders who attended the Van Creveldkliniek, University Medical Center Utrecht, between 1989 and 2025. Patients with moderate or severe haemophilia A or B (FVIII/FIX <5%) or Von Willebrand’s disease (VWD) with a FVIII activity <5% were included. All types of primary THA or TKA were included. All patients were followed according to standard care. The primary outcome was time to prosthesis failure, defined as revision or indication for revision (but patients are inoperable or refuse), measured in years.
General Design
- Type
- Health records
- Data collection type
- Retrospective
- Design
- Longitudinal
- Design description
- Single center retrospective cohort study,
- Start/End data collection
- 1989 until 2026
- PID
- https://doi.org/10.71739/gp7d-fx35
Population
- Countries
- Netherlands (the)
- Number of participants
- 192
- Population age groups
- Adult (18+ years)
- Main medical condition
- XIII Diseases of the musculoskeletal system and connective tissue
- M00-M25 Arthropathies
- M15-M19 Arthrosis
- M15.0 Polyarthrosis - Primary generalized (osteo)arthrosis
- Other inclusion criteria
- Patients with moderate or severe haemophilia A or B (FVIII/FIX <5%) or Von Willebrand’s disease (VWD) with a FVIII activity <5% were included, as arthropathy in patients with these factor levels is assumed to be bleeding related [29]. All types of primary THA or TKA were included. All patients were followed according to standard care. Patients could be included multiple times with distinct joints.
Organisations
Lead organisations
- University Medical Center Utrecht (UMC)
Van CreveldkliniekNetherlands (the)https://www.umcutrecht.nlData originator, Data holder, Researcher
Additional organisations
- University Medical Center Utrecht (UMC)
OrthopaedicsNetherlands (the)https://www.umcutrecht.nl - University Medical Center Utrecht (UMC)
Radiology and Nuclear MedicineNetherlands (the)https://www.umcutrecht.nl
Contributors
- dr. Lize van VulpenUniversity Medical Center Utrechtl.f.d.vanvulpen-2@umcutrecht.nl
Principal Investigator
- drs. Gijs AertssenUniversity Medical Center Utrechtg.aertssen@umcutrecht.nl
Primary contact, Project leader
Available Data & Samples
Data categories
Medical records
Areas of information
- Administrative information
- Date and time-related information
- Socio-demographic and economic characteristics
- Age/birthdate
- Symptoms and signs
- Symptoms and signs involving nervous and musculoskeletal systems (R25-R29)
- Non-pharmacological interventions
- Surgical interventions
- Physical environment
- Housing characteristics
- Geocodes for residential address
- Built environment/neighbourhood characteristics
- Workplace characteristics
- Radiation exposure
- Chemical exposure
- Chemicals
- Persistent organic pollutants
- Metals & elements
- Other chemicals
- Water DBPs
- Non-targeted / suspect screening of chemicals
- Biological exposure
- Food environment
- Natural environment
- Air pollution (outdoor)
- Air pollution (indoor)
- Noise, traffic, or light
- Meteorology
- Other physical environment characteristics
- Light
Subpopulations
List of subpopulations for this resource
| Name | Description | Number of participants | |
|---|---|---|---|
No results for current selection |
Collection events
List of collection events defined for this resource
| Name | Description | Participants | Start end year | |
|---|---|---|---|---|
No results for current selection |
Access conditions
- Data access conditions
- health or medical or biomedical research
- Data access fee
- false
- Release type
- Closed dataset
- Prelinked
- false
Funding & Acknowledgements
- Funding
- This research received no specific funding from any public, commercial, or not-for-profit organization.